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1.
Jt Dis Relat Surg ; 35(2): 439-442, 2024 Apr 26.
Article in English | MEDLINE | ID: mdl-38727126

ABSTRACT

Tension band wiring (TBW) is one of the most commonly used fixation techniques to fix olecranon osteotomies. Hardware prominence has been the most commonly reported complication of TBW. However, distal migration of Kirschner (K)-wire after TBW fixation for olecranon osteotomy has not been reported. In this case report, we presented distal migration of K-wire detected nine months after initial surgery in a 46-year-old male patient. The patient was operated on for an intraarticular distal humerus fracture using an olecranon osteotomy. The osteotomy was fixed with TBW fixation. The patient missed routine follow-ups and presented to the outpatient clinic with a complaint of skin irritation at the elbow nine months after the surgery. On radiological examination, distal migration of one K-wire was detected. The K-wire was surgically removed without any complication. Physicians should be aware of possible complications of TBW and remove fixation after fracture union to avoid unexpected complications.


Subject(s)
Bone Wires , Foreign-Body Migration , Olecranon Process , Osteotomy , Humans , Bone Wires/adverse effects , Male , Middle Aged , Olecranon Process/injuries , Olecranon Process/surgery , Olecranon Process/diagnostic imaging , Osteotomy/adverse effects , Osteotomy/methods , Osteotomy/instrumentation , Foreign-Body Migration/surgery , Foreign-Body Migration/diagnostic imaging , Foreign-Body Migration/etiology , Humeral Fractures/surgery , Humeral Fractures/diagnostic imaging , Fracture Fixation, Internal/adverse effects , Fracture Fixation, Internal/methods , Fracture Fixation, Internal/instrumentation , Device Removal/methods , Elbow Joint/surgery , Elbow Joint/diagnostic imaging , Intra-Articular Fractures/surgery , Intra-Articular Fractures/diagnostic imaging
2.
Cureus ; 16(2): e55281, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38558643

ABSTRACT

Objectives This study aims to investigate the negative prognostic indicators of pediatric and adult trigger finger surgery patients concerning complications, recurrence, and satisfaction. Methods A retrospective study was conducted on 61 patients with a total of 91 trigger fingers, including 31 in children and 30 in adult patients, all of whom were treated using a standardized surgical technique. The study considered several demographic and clinical factors, including age, gender, dominant hand, body mass index, occupation, history of trauma, single or multiple finger involvement, staging according to Green classification, diabetes mellitus, comorbidities, recurrence, revision surgery, utilization of non-surgical treatment methods, need for rehabilitation after surgery, time to return to work, the time interval from clinic initiation to the surgery, satisfaction and the duration of the follow-up period. In addition, the quick version of the disabilities of the arm, shoulder, and hand (QDASH); and the visual analog scale (VAS) were used to assess patients' data. Results In adult patients, a statistically significant relationship was observed between the increasing grade of the Green stage and complication rate (p<0.001), recurrence (p<0.001), and lower satisfaction (p<0.001). No statistically significant relationship was identified between Green's classification and complications (p=0.129), recurrence (p=0.854), or satisfaction (p=0.143) in pediatric patients. While a statistically significant relationship existed between the time interval from clinic initiation to surgery and complications (p=0.033) in adult patients, no significant relationships were observed for recurrence or satisfaction. Conversely, there was no statistically significant relationship between the time interval from clinic initiation to surgery and complications, recurrence, or satisfaction in pediatric patients. Conclusion This study demonstrates that increasing the grade of the Green stage and duration of symptoms before surgery were the substantial factors contributing to prognosis in adult patients but not in pediatric patients. These findings can assist physicians during patients' treatment management. We suggest that physicians consider these factors for patients' satisfaction.

3.
Wilderness Environ Med ; 35(1): 88-93, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38379488

ABSTRACT

Wild boar-inflicted nerve injuries have been very rarely reported in the literature. A 62-year-old man was attacked by a wild boar in eastern Turkey and brought to the emergency department. He had 5 lacerations on the lower extremities and 2 on the posterior thoracic region. In addition to soft tissue lacerations, he sustained a complete laceration of the left common peroneal nerve with a foot drop. The common peroneal nerve was repaired primarily the day after the attack. The patient was discharged after a short hospital stay without any immediate complications; however, at the 10-mo follow-up, he still had a left foot drop.


Subject(s)
Lacerations , Peroneal Neuropathies , Animals , Humans , Male , Middle Aged , Lower Extremity , Peroneal Nerve , Sus scrofa
4.
Orphanet J Rare Dis ; 19(1): 53, 2024 Feb 09.
Article in English | MEDLINE | ID: mdl-38336741

ABSTRACT

BACKGROUND: Cerebrotendinous Xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder caused by loss of function variants in the CYP27A1 gene which encodes sterol 27-hydroxylase, on chromosome 2q35. Although the symptoms begin commonly in infancy, CTX diagnosis is often delayed. The aim of this study is to review the orthopedic findings of the disease by providing an overview of the clinical features of the disease. It is to raise awareness of this condition for which early diagnosis and treatment are important. METHODS: We retrospectively evaluated the clinical, laboratory, radiological, and genetic findings of eight patients from four families who were admitted to our Orthopedics and Traumatology Department between 2017 and 2022 due to bilateral Achilles tendon xanthomas, were found to have high cholestanol and CYP27A1 gene mutations. RESULTS: The mean age of patients was 37, and five of them were male. The mean age at the onset of symptoms was 9.25 years. The mean age of initial diagnosis was 33.75 years. Between symptom onset and clinical diagnosis, an average delay of 24.5 years was observed. All patients had bilateral Achilles tendon xanthoma. Notably, a novel variant (c.670_671delAA) in CYP27A1 gene was identified in three patients who also presented with peripheral neuropathy and bilateral pes cavus. One patient had osteoporosis and four patients had osteopenia. Five patients had a history of bilateral cataracts. Furthermore, three of the patients had early-onset chronic diarrhea and three of the patients had ataxia. Two of the patients had epilepsy and seven of the patients had behavior-personality disorder. All patients had low intelligence, but none of them had cardiac disease. CONCLUSION: We present the diagnostic process and clinical features which the largest CTX case series ever reported from single orthopedic clinic. We suggest that patients with normal cholesterol levels presenting with xanthoma being genetically analyzed by testing at their serum cholestanol level, and that all siblings of patients diagnosed with CTX be examined.


Subject(s)
Cholestanetriol 26-Monooxygenase , Xanthomatosis, Cerebrotendinous , Adult , Child , Female , Humans , Male , Cholestanetriol 26-Monooxygenase/genetics , Cholestanol/therapeutic use , Retrospective Studies , Xanthomatosis/genetics , Xanthomatosis, Cerebrotendinous/diagnosis , Xanthomatosis, Cerebrotendinous/genetics
7.
Acta Orthop Traumatol Turc ; 57(6): 315-321, 2023 Nov.
Article in English | MEDLINE | ID: mdl-38454212

ABSTRACT

OBJECTIVE: This study aimed to describe the type and number of traumatic injuries seen after devastating earthquakes and to evaluate the difficulties experienced in the treatment process in a primary affected center. METHODS: Out of the 2176 patients who were treated in the emergency department, 372 (199 male and 173 female) patients with complete data were included in this single-center retrospective study. In addition to the demographic characteristics of the patients, orthopedic injuries, other organ system injuries, type of injury, treatments, mechanisms of injury, and time of presentation to the emergency department were recorded. RESULTS: The most common age group for injury was 20-30 years old, consisting of 73 patients (19.62%), and the second most common age group was between 40 and 50, with 72 patients (19.35%). Injury after being trapped under rubble was seen in 152 (40.86%) patients, while non-debris causes were more common in 220 patients (59.14%). The most common site of injury was in the lower extremities, with 111 patients (29.84%), while multiple injuries were seen in 109 patients (29.3%). Lower extremity fractures were mostly seen in long bones such as the femur (12.28%) and tibia (11.4%). Upper extremity fractures, especially those due to falls, were most frequently in the distal radius (8.77%). After triage, 117 patients (31.45%) were hospitalized, whereas the majority of patients (58.33%) were discharged from the emergency department. CONCLUSION: This study has shown us that injuries following major earthquakes are of a wide spectrum and occur in large numbers and in a very short time. Even in a well-equipped hospital that is not affected by an earthquake, there are many barriers to appropriate management. The first 24 hours after an earthquake are critical. This period should be kept in mind while organizing and taking necessary precautions, and early responses to earthquakes should be meticulously planned.


Subject(s)
Earthquakes , Fractures, Bone , Multiple Trauma , Humans , Male , Female , Young Adult , Adult , Retrospective Studies , Fractures, Bone/epidemiology , Multiple Trauma/epidemiology , Hospitals
8.
Ulus Travma Acil Cerrahi Derg ; 28(9): 1335-1339, 2022 Sep.
Article in English | MEDLINE | ID: mdl-36043928

ABSTRACT

BACKGROUND: The aim of this study is to evaluate the musculoskeletal injuries related with 24 January 2020 Elazig/Türkiye earthquake and their treatment protocols. METHODS: Data of patients applied to Inönü University Medical Faculty Hospital, Elazig Training and Research Hospital and Malatya Training and Research Hospital emergency departments within 48 h after the earthquake, were evaluated retrospectively. Age, gender, soft tissue injuries and sites, fracture sites and types, fracture etiology, and treatment methods were evaluated. RESULTS: 247 patients were evaluated. 118 were women and 139 were men. There were 24 (9.7%) pediatric patients. Mean age was 37.3 (1-92) years. Waist majority of injuries were simple soft-tissue injuries. There were 103 fractures in 86 patients. Thirty-eight patients' fractures were treated surgically. CONCLUSION: Every major disaster warrants retrospective studies so we can learn how to improve all levels of Emergency Medical Services. Great proportion of Elazig earthquake victims had only simple soft tissue injuries such as sprain, laceration, or contusion. Many patients were injured due to reasons indirectly related to the destruction brought by the earthquake. Panic caused by the earth-quake caused more injury than the destruction it brought.


Subject(s)
Disasters , Earthquakes , Emergency Medical Services , Fractures, Bone , Soft Tissue Injuries , Wounds and Injuries , Adult , Child , Female , Fractures, Bone/epidemiology , Fractures, Bone/etiology , Humans , Male , Retrospective Studies , Soft Tissue Injuries/epidemiology , Soft Tissue Injuries/etiology
9.
J Bank Financ ; 133: 106223, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34898822

ABSTRACT

In response to the COVID-19 crisis, the U.S. government passed the Coronavirus Aid, Relief, and Economic Security (CARES) Act on March 27, 2020, creating the Paycheck Protection Program (PPP), among others, to aid small businesses and their employees. Most PPP loans were administered by commercial banks in return for fees, and the banks bore little monitoring costs or risks, since PPP loans were forgivable by the government. I analyze if PPP loans of up to $1 million were net substitutes or complements for conventional small business loans of the same size for the PPP-issuing banks. The $1 million upper bound roughly corresponds to credits to the smallest firms that are often financially constrained. Using Call Report data through 2020:Q4, I find significant net complementarities. An additional dollar of PPP credit of up to $1 million had multiplier effects on conventional loans to the smallest firms of about an extra dollar.

10.
Eklem Hastalik Cerrahisi ; 30(1): 53-60, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30885109

ABSTRACT

OBJECTIVES: This study aims to present the early-period outcomes of patients with Dupuytren's contracture (DC) treated with percutaneous needle aponeurotomy technique. PATIENTS AND METHODS: This retrospective study included 28 patients (20 males, 8 females; mean age 63 years; range, 44 to 88 years) (75 fingers) treated with percutaneous aponeurotomy due to DC between November 2011 and December 2015. Patients were evaluated according to their demographic characteristics, presence of additional disease, family history, history of drug use, complication rate, recurrence development, postoperative patient satisfaction, reoperational request, postoperative Disability of Arm Shoulder and Hand Questionnaire and visual analog scale scores. RESULTS: Mean follow-up duration was 29 months (range, 12 to 60 months). In the postoperative satisfaction questionnaire, 92.9% (n=26) of patients stated that they were satisfied. In the questionnaire of reoperation request, 82.1% (n=23) of patients accepted the reoperation. While the complication rate was 39.3%, recurrence rate was 35.7%. CONCLUSION: Percutaneous needle aponeurotomy technique may be an effective, simple, and safe method for the treatment of DC.


Subject(s)
Aponeurosis/surgery , Dupuytren Contracture/surgery , Fasciotomy/methods , Needles , Adult , Aged , Aged, 80 and over , Fasciotomy/adverse effects , Fasciotomy/instrumentation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Patient Satisfaction , Recurrence , Reoperation , Retrospective Studies , Surveys and Questionnaires , Treatment Outcome
11.
Acta Orthop Traumatol Turc ; 53(1): 40-44, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30409393

ABSTRACT

OBJECTIVES: We aimed to present preliminary result of one portal endoscopic assisted release of first dorsal compartment at wrist in a case series with de Quervain disease as a minimal invasive surgical method. MATERIALS AND METHODS: The patients, who underwent an endoscopic-assisted release of the first extensor compartment for de Quervain's disease by same hand surgeon between 2015 and 2017, were retrospectively analyzed. Operative treatment was considered if the patients did not respond to non-operative treatment including oral anti-inflammatory medications, splinting, and steroid injection. Surgical release was recommended after minimum four months of unsuccesful non-operative treatment, including a steroid injection. 10 wrists were treated with one portal endoscopic assisted release. All patients were evaluated at an average of 16.1 months follow-up using visual analog scale (VAS) pain ratings and the Disabilities of Arm, Shoulder and Hand (DASH) score. RESULTS: The mean operating time was 13.9 min (range, 10-21min). The mean VAS and DASH scores were improved from 8.2 to 1.9 and 70.51 to 2.81 respectively. No significant difference was found between operated and non-operated arms in postoperative pinch and strengths. Transient superficial radial nerve paresthesia (two wrists) and significant scar tenderness (one) were identified in three cases. There was no patient that complain of unsightly scar and tendon subluxation. CONCLUSIONS: One portal endoscopic assisted release of the extensor compartment is an effective and safe minimal invasive procedure with similar complication rates reported previously in open and endoscopic procedures in patients with de Quervain's disease who are unresponsive to non-operative treatments. LEVEL OF EVIDENCE: Level IV Therapeutic Study.


Subject(s)
Arthralgia , Arthroscopy , De Quervain Disease , Tenotomy , Adult , Aged , Arthralgia/diagnosis , Arthralgia/surgery , Arthroscopy/adverse effects , Arthroscopy/methods , De Quervain Disease/diagnosis , De Quervain Disease/physiopathology , De Quervain Disease/surgery , Decompression, Surgical/methods , Female , Humans , Male , Middle Aged , Pain Measurement , Retrospective Studies , Tenotomy/adverse effects , Tenotomy/methods , Treatment Outcome , Turkey , Wrist Joint/physiopathology , Wrist Joint/surgery
13.
Eklem Hastalik Cerrahisi ; 28(2): 107-13, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28760127

ABSTRACT

OBJECTIVES: This study aims to investigate the effect of platelet-rich plasma (PRP) on femoral head osteonecrosis and compare it with bone marrow injection and core decompression. MATERIALS AND METHODS: A total of 30 healthy, adult, male New Zealand white rabbits (mean weight 2.25±0.15 kg; range 2.0 to 2.5 kg) were used in the study. To create experimental osteonecrosis in all rabbits, 40 mg/kg methylprednisolone acetate was applied intramuscularly. Rabbits were randomly allocated into three groups with 10 rabbits in each: drilling group, PRP group, and bone marrow group. The non-drilled hips of the drilling group were identified as the control group. RESULTS: Rate of necrotic bone was lower in the PRP group compared to other groups. Highest rate of necrotic bone was detected in the control group. New bone formation rate was higher in the PRP group compared to other groups. Lowest new bone formation rate was determined in the control group. Inflammatory reaction rate was higher in the PRP group compared to other groups. CONCLUSION: Platelet-rich plasma injection may play a positive role in the treatment of steroid-associated osteonecrosis in a rabbit model.


Subject(s)
Femur Head Necrosis , Femur Head/surgery , Platelet-Rich Plasma , Animals , Biological Factors/pharmacology , Bone Marrow Transplantation/methods , Decompression, Surgical/methods , Disease Models, Animal , Femur Head Necrosis/chemically induced , Femur Head Necrosis/therapy , Male , Methylprednisolone/pharmacology , Rabbits , Treatment Outcome
14.
Eklem Hastalik Cerrahisi ; 28(1): 50-4, 2017 Apr.
Article in Turkish | MEDLINE | ID: mdl-28291440

ABSTRACT

Gluteal compartment syndrome is a rather rare syndrome often leading to severe sequelae, sepsis, renal failure, and even death due to delayed diagnosis. Establishing early diagnosis is essential to prevent complications associated with ischemia. In this article, we report a 56-year-old male patient who developed gluteal compartment syndrome after incisional hernia and nephrectomy surgery in lateral decubitus position. Gluteal muscle insufficiency developing after fasciotomy and Trendelenburg gait improved within two years.


Subject(s)
Compartment Syndromes/etiology , Incisional Hernia/surgery , Nephrectomy/adverse effects , Postoperative Complications/etiology , Buttocks , Compartment Syndromes/physiopathology , Compartment Syndromes/surgery , Fasciotomy , Humans , Male , Middle Aged , Postoperative Complications/surgery
15.
J Am Podiatr Med Assoc ; 107(1): 85-89, 2017 Jan.
Article in English | MEDLINE | ID: mdl-28271939

ABSTRACT

Cerebrotendinous xanthomatosis is a rare, autosomal recessive, lipid storage disease with accumulation of cholestanol in most tissues, particularly in the Achilles tendons. We described a 23-year-old female patient who had progressive painfull swelling of both Achilles tendons due to cerebrotendinous xanthomatosis. We performed surgery on both-side Achilles tendon tumors. Wide degenerative areas of the tendons were resected, and the flexor hallucis longus tendon was harvested and transferred to reconstruct motion function.


Subject(s)
Achilles Tendon , Tendinopathy/etiology , Xanthomatosis, Cerebrotendinous/complications , Xanthomatosis/etiology , Female , Humans , Tendinopathy/diagnostic imaging , Tendinopathy/surgery , Xanthomatosis/diagnostic imaging , Xanthomatosis/surgery , Young Adult
16.
J Wrist Surg ; 6(1): 70-73, 2017 Feb.
Article in English | MEDLINE | ID: mdl-28119799

ABSTRACT

Musculoskeletal system is involved in about 20% of the patients diagnosed with tuberculosis. Although musculoskeletal tuberculosis generally affects spine and large joints (hip and knee), hand involvement of the tuberculosis is seen in 10% of the patients with musculoskeletal involvement and also isolated tuberculosis of hand or wrist is much rarer. In the following report, we discuss the case of a 23-year-old male patient who was diagnosed with isolated tuberculosis of the capitate and triquetrum bone. The patient presented with a nonhealing sinus on the left wrist joint. Imaging revealed lytic lesions of the capitate and triquetrum. The diagnosis of tuberculosis was confirmed by histopathological examination on the bone specimen obtained from the debridement and curettage. Antituberculosis therapy was started postoperatively and 1 month later, healing of the sinus was observed. There was no sign of reactivation seen at follow-up 22 months after treatment.

17.
Eklem Hastalik Cerrahisi ; 27(3): 132-7, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27902167

ABSTRACT

OBJECTIVES: This study aims to present our clinical results obtained in arthroscopic limited intercarpal fusion performed without using bone graft in patients with Kienböck's disease. PATIENTS AND METHODS: The study included 11 patients with Kienböck's disease (6 males, 5 females; mean age 28.9 years; range 14 to 51 years) who were performed arthroscopic lunate excision and scaphocapitate fusion between November 2012 and December 2013. Bain and Begg Arthroscopic Classification was used for the staging of Kienböck's disease. Quick Disabilities of Arm, Shoulder and Hand and Mayo Wrist scorings were used for clinical evaluation. RESULTS: Intercarpal fusion was achieved in approximately 7.2 weeks. There was a statistically significant difference in Mayo Wrist scores of postoperative third and sixth months and pre- and postoperative Quick Disabilities of Arm, Shoulder and Hand scores. There was no postoperative complication. CONCLUSION: According to our study findings, arthroscopic limited intercarpal fusion without using bone graft may be performed in patients with Kienböck's disease. Satisfactory clinical and functional results were obtained as a result of treatment with this method in stage 3 and 4 Kienböck's disease.


Subject(s)
Arthrodesis/methods , Arthroscopy , Bone Transplantation , Lunate Bone/surgery , Osteonecrosis/surgery , Adolescent , Adult , Disability Evaluation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Wrist Joint/physiopathology , Young Adult
18.
J Pak Med Assoc ; 66(6): 757-60, 2016 06.
Article in English | MEDLINE | ID: mdl-27339584

ABSTRACT

Knee dislocation is a relatively rare condition of all orthopaedic injuries. Accompanying multiple ligament injuries are common after knee dislocations. A 41-year-old male presented to the emergency department suffering from right knee dislocation in June 2013. The patient had anterior cruciate ligament, medial collateral ligament (MCL), medial patellofemoral ligament (MPFL) rupture, and lateral meniscal tear. A single-bundle anatomic reconstruction, medial collateral ligament reconstruction, medial patellofemoral ligament reconstruction and meniscus repair were performed in single session. At twelve months follow-up; there was 160º flexion and 10° extension knee range of motion. Lysholm knee score was 90. Extensive forces can cause both MCL and MPFL injury due to overload and the anatomical relationship between these two structures. Therefore, patients with valgus instability should be evaluated for both MPFL and MCL tears to facilitate successful treatment.


Subject(s)
Knee Dislocation/complications , Patellar Dislocation/etiology , Adult , Humans , Joint Instability , Knee Joint , Ligaments/injuries , Male , Multiple Trauma
19.
Acta Orthop Traumatol Turc ; 49(6): 579-85, 2015.
Article in English, Turkish | MEDLINE | ID: mdl-26511682

ABSTRACT

OBJECTIVE: The aim of this study is to report our institution's experience regarding the use of open tibial inlay technique in patients undergoing single-stage combined posterior cruciate ligament (PCL) reconstruction. METHODS: Records of 17 patients who underwent PCL reconstruction with tibial inlay technique were retrospectively reviewed. Patients with ipsilateral femoral or tibial osteochondral avulsion fractures or ipsilateral concomitant tibia and femur shaft fractures were excluded. Out of these 17 patients, six cases underwent anterior cruciate ligament (ACL) + PCL reconstruction, nine cases underwent ACL+ PCL + posterolateral corner reconstruction, one case underwent ACL + PCL + MCL reconstruction and one case underwent ACL+ PCL + posterolateral corner + MCL reconstruction. Mean follow-up was 14.27±6.77 (range: 6-30) months. RESULTS: In preoperative assessments, all patients had 3+ posterior laxity in posterior drawer test; at final follow-up, 6 patients had 0 laxity, 7 patients had 1+ laxity, and 4 patients had 2+ laxity (p<0.001). International Knee Documentation Committee (IKDC) objective evaluation showed severe disability in all patients preoperatively, whereas 5 knees were grade A, 8 knees were grade B, 3 knees were grade C, and 1 knee was grade D at final follow-up. Mean IKDC subjective score was 75.22±7.53 at final follow-up. Postoperatively, mean side-to-side difference in KT-1000 arthrometer measurement was 2.45±1.80 mm. At final follow-up, mean range of motion (ROM) was 0º on extension and 123.56±6.31º on flexion. CONCLUSION: Open tibial inlay approach is beneficial during PCL reconstruction. Further study is warranted to establish its effectiveness on functional outcomes and prevention of complications.


Subject(s)
Anterior Cruciate Ligament Reconstruction/methods , Joint Instability/surgery , Knee Injuries/surgery , Knee Joint/surgery , Posterior Cruciate Ligament/surgery , Tibia/surgery , Achilles Tendon/surgery , Adolescent , Adult , Arthroscopy/methods , Female , Follow-Up Studies , Humans , Male , Range of Motion, Articular , Retrospective Studies , Treatment Outcome , Young Adult
20.
J Orthop Surg Res ; 10: 110, 2015 Jul 16.
Article in English | MEDLINE | ID: mdl-26173978

ABSTRACT

PURPOSE: The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. METHODS: Full-thickness chondral defects of 3 × 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and the rabbits were then divided into three groups according to treatment: Group 1 received only microfracture (mfx), Group 2 received mfx plus intraarticular ACP, and Group 3 received mfx; the defect was covered by the periosteum, and then, ACP was applied subperiosteally and intraarticularly. Twelve weeks after injection, the animals were sacrificed and the femoral condyles were evaluated macroscopically and histologically by hematoxylin-eosin staining. Then, histological sections were scored using the International Cartilage Repair Society (ICRS) visual histological scale. RESULTS: Findings showed that in both mfx/ACP-treated groups, the defects were filled regularly and smoothly, the defects had a greater fill and good integration into the surrounding host tissue, and the repair matrix had more hyaline-like character. On the other hand, defects were filled with an irregular, fibrous cartilage in the mfx-treated group. Histological scores in Group 2 and Group 3 were better compared to Group 1. CONCLUSION: In the present study, we were able to demonstrate a beneficial effect of intraarticular administration of ACP as a coadjuvant of microfractures in order to regenerate hyaline-like cartilage in full-thickness chondral lesions in a rabbit model.


Subject(s)
Autografts , Fractures, Cartilage/pathology , Fractures, Cartilage/therapy , Knee Joint/pathology , Plasma , Animals , Cartilage, Articular/pathology , Injections, Intra-Articular , Rabbits
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